Health Professionals Section

Recent research findings


'Continuous glucose monitoring and intensive treatment of type 1 diabetes.'
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group.
N Engl J Med. 2008; 359(14):1464-76.
Read abstract on Pubmed

'General and abdominal adiposity and risk of death in Europe.'
Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, et al.
N Engl J Med. 2008; 359(20):2105-20.
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'Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study.'
Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, Porter L; for the DURATION-1 Study Group.
Lancet 2008; 372: 1240–50.
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'The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.'
Belch J, MacCuish A, Campbell I, Cobbe S, Taylor R, et al.
BMJ. 2008 Oct 16;337:a1840.
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'Aspirin in type 2 diabetes: is there any evidence base?'
Walsh M, Spurling G.
BMJ. 2008 Oct 16;337:a1902.
Read extract at bmj.com link out

'Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes'
N Engl J Med. 359 (15): 1565-76, Oct 2008.
Holman RR, Paul SK, Bethel MA, Neil HA, Matthews DR.
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10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
N Engl J Med. 359 (15): 1577-89, Oct 2008.
Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA.
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Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study.
BMJ. 337:a918. doi: 10.1136/bmj.a918, Aug 2008.
Gallego PH, Craig ME, Hing S, Donaghue KC.
Read article at BMJ website (free full text) link out

Screening for type 2 diabetes mellitus in adults: U.S. Preventive Services Task Force recommendation statement.
Ann Intern Med. 148 (11): 846-54, June 2008.
U.S. Preventive Services Task Force.
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Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.
Lancet. 372 (9638): 547-53, August 2008.
Mann JF, Schmieder RE, McQueen M, Dyal L et al.; ONTARGET investigators.
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Editorial comment regarding the ONTARGET study (subscription required) link out

'Consensus Statement: A New Look at Screening and Diagnosing Diabetes Mellitus '
J Clin Endocrinol Metab. 93: 2447-2453, July 2008.
Christopher D. Saudek, William H. Herman, David B. Sacks, Richard M. Bergenstal, David Edelman, and Mayer B. Davidson
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'Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study.'
BMJ. 336 (7657): 1348-51, June 14, 2008.
Martinez-Gonzalez MA. de la Fuente-Arrillaga C. Nunez-Cordoba JM. Basterra-Gortari FJ. Beunza JJ. Vazquez Z. Benito S. Tortosa A. Bes-Rastrollo M.
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'Cost effectiveness of self monitoring of blood glucose in patients with non-insulin treated type 2 diabetes: economic evaluation of data from the DiGEM trial.'
BMJ. 336 (7654): 1177-1180, May 24, 2008
Judit Simon, Alastair Gray, Philip Clarke, Alisha Wade, Andrew Neil, Andrew Farmer on behalf of the Diabetes Glycaemic Education and Monitoring Trial Group
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'Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.'
N Engl J Med . 358(24):2560-72, June 12, 2008
ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, et al .
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Editorial comment by Dluhy & McMahon at NEJM link out
Editorial comment by Cefalu at NEJM (free full text) link out

'Effects of intensive glucose lowering in type 2 diabetes.'
N Engl J Med . 358(24):2545-59, June 12, 2008
Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT.
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Editorial comment by Dluhy & McMahon at NEJM link out
Editorial comment by Cefalu at NEJM (free full text) link out

'Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study.'
Lancet 371(9626): 1777-82, May 24, 2008
Harjutsalo V, Sjöberg L, Tuomilehto J.
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'Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.'
Lancet 371(9626): 1753-60, May 24, 2008
Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, Hu Y, Zhou Z, Yan X, Tian H, Ran X, Luo Z, Xian J, Yan L, Li F, Zeng L, Chen Y, Yang L, Yan S, Liu J, Li M, Fu Z, Cheng H
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'The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study.'
Lancet 371 :1783-1789, 24 May, 2008
Li G, Zhang P, Wang J, Gregg EW, Yang W, Gong Q, Li H, Li H, Jiang Y, An Y, Shuai Y, Zhang B, Zhang J, Thompson TJ, Gerzoff RB, Roglic G, Hu Y, Bennett PH.
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'Metformin versus insulin for the treatment of gestational diabetes.'
N Engl J Med 358(19):2003-15, May 8, 2008
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG Trial Investigators.
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NZSSD Expert Opinion comment on the MiG trial (24KB)

'Hyperglycemia and adverse pregnancy outcomes.'
N Engl J Med 358(19):1991-2002, May 8, 2008
HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, Hadden DR, McCance DR, Hod M, McIntyre HD, Oats JJ, Persson B, Rogers MS, Sacks DA.
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NZSSD Expert Opinion comment on the HAPO study (24KB)

'Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial.'
Lancet 371(9618):1073-84, March 29, 2009
Bretzel RG, Nuber U, Landgraf W, Owens DR, Bradley C, Linn T
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'Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes'
N Engl J Med 358:580-91, February 7, 2008
Gaede P, Lund-Andersen H, Parving HH, Pedersen O
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'Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes'
N Engl J Med 357:1716-30, October 25, 2007
Holman RR, Thorne KI, Farmer AJ, Davies MJ, Keenan JF, Paul S, Levy JC
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'Meta-analysis: Effect of Monotherapy and Combination Therapy with Inhibitors of the Renin–Angiotensin System on Proteinuria in Renal Disease'
Ann Intern Med 148:30-48, 2008
Kunz R, Friedrich C, Wolbers M, Mann JFE
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'Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes: A Randomized Controlled Trial'
JAMA 299(3):316-323, 2008
 Dixon JB, O'Brien PE, Playfair J, Chapman L, Schachter LM, Skinner S, Proietto J, Bailey M, Anderson M
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